GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2736345 | 1 | rs2736345 | chr8:11352485 | BLK | chr8:11351521-11422107:+ | -0.39 | -4.9 | 3.99E-6 | Systemic lupus erythematosus |
| THYM | cis | rs2742234 | 1 | rs2742234 | chr10:43612609 | CSGALNACT2 | chr10:43633934-43680747:+ | 0.33 | 4.71 | 8.36E-6 | Hirschsprung disease |
| THYM | cis | rs30187 | 1 | rs27529 | chr5:96126308 | ERAP1 | chr5:96096515-96149837:- | -0.33 | -4.3 | 4.15E-5 | Ankylosing spondylitis |
| THYM | cis | rs9457247 | 1 | rs2757042 | chr6:167371234 | RNASET2 | chr6:167343008-167412795:- | 0.44 | 7.05 | 2.87E-10 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs2757047 | chr6:167374489 | RNASET2 | chr6:167343008-167412795:- | 0.47 | 7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs2806864 | 1 | rs2767342 | chr1:117469637 | SLC22A15 | chr1:116519119-116612672:+ | -0.56 | -4.27 | 4.6E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs7849270 | 1 | rs2768630 | chr9:131866388 | CRAT | chr9:131857075-131873070:- | -0.47 | -5.42 | 4.57E-7 | Blood metabolite ratios |
| THYM | cis | rs9457247 | 1 | rs2769347 | chr6:167371737 | RNASET2 | chr6:167343008-167412795:- | 0.46 | 7.38 | 6.04E-11 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs2769352 | chr6:167378619 | RNASET2 | chr6:167343008-167412795:- | 0.45 | 7.53 | 2.89E-11 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs2769354 | chr6:167379771 | RNASET2 | chr6:167343008-167412795:- | 0.47 | 7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs2786098 | 1 | rs2786119 | chr1:197329535 | CFHR1 | chr1:196748292-196801316:+ | -0.55 | -4.13 | 7.79E-5 | Asthma |
| THYM | cis | rs2806864 | 1 | rs2806862 | chr1:117467173 | SLC22A15 | chr1:116519119-116612672:+ | 0.58 | 4.55 | 1.58E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs2806864 | 1 | rs2806863 | chr1:117469513 | SLC22A15 | chr1:116519119-116612672:+ | -0.59 | -4.39 | 2.96E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs2806864 | 1 | rs2806864 | chr1:117469781 | SLC22A15 | chr1:116519119-116612672:+ | -0.59 | -4.39 | 2.96E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs10804591 | 1 | rs2811434 | chr3:129339615 | TMCC1 | chr3:129366637-129612403:- | 0.31 | 4.24 | 5.18E-5 | Waist-to-hip ratio adjusted for body mass index |